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Inner beauty carrickfergus12/21/2023 We also aimed to collect decisive data for the development of a food ingredient for inner beauty purposes. mume extracts to the surface of the skin to investigate whether the extracts and amygdalin could inhibit skin aging in a UV irradiation model. This study focuses on alleviating skin senescence after the application of P. mume seed as a valuable product warrants investigation. Because the dry weight of the seed (including the stone) comprises 40.4% of the whole fruit, it is a plentiful by-product. mume seed were wasted annually as a by-product in Wakayama Prefecture, a major production area in Japan. mume fruit production in Korea was worth approximately 7.2 million US dollars in 2010, 7.4 million in 2011, 13.9 million in 2012, and 16.7 million in 2013. According to the statistics from the Ministry of Agriculture, Food, and Rural Affairs in Korea, P. mume fruit was estimated as 7,743 tons from 1,034 hectares of Korean farmlands. mume seed repressed the damage caused by hydrogen peroxide in granulosa cells. Furthermore, 3,4-dihydroxybenzaldehyde isolated from the P. mume 70% ethanol extract inhibited α-glucosidase activity and reduced blood glucose levels in obese and diabetic mice. mume fruits repressed glucose uptake in C2C12 cells and regulated glucose intolerance in a high-fat diet-fed mouse model, and the leaf extract lowered blood glucose levels in diabetic mice. Mumeose, an acylated sucrose isolated from the flower buds, has demonstrated an inhibitory effect against aldose reductase. mume can inhibit melanogenesis in B16 melanoma 4A5 cells. The methanolic extract of the flower buds of P. The major compound of the polysaccharide fraction of P. Its fruit is called “ume” in Japanese and “maesil” in Korean. It is called “Japanese apricot” or “Japanese plum” in Japan, “Chinese mei” in China, and “maehwa” in Korea. et Zucc of the family Rosaceae has been cultivated in East Asia, including China, Japan, and Korea, for more than 3,000 years. Thus, the photoaging model was used in this study. Intrinsic skin aging is also affected by photoaging. Of these two types of skin aging, photoaging is easier to study because of ease of control, rapid stimulation, possible dramatic effects using novel materials, and the low assay cost. Intrinsic skin aging is accompanied by wrinkles, laxity, a dry or rough skin surface, a thin epidermis, and a saggy appearance. Photoaging is associated with various symptoms, including a thickened epidermis, deep furrows, reddened skin caused by burns, differently pigmented areas, severe skin atrophy, and reduced collagen fibers. Skin aging is classified as either intrinsic (chronological) skin aging and/or photoaging. Furthermore, facial skin senescence differs among individuals of the same age. Although skin senescence occurs with increasing age, it can be affected by ultraviolet (UV) radiation. Skin aging is relevant to social activity because a good appearance improves self-confidence and creates a favorable impression. IntroductionĪlthough aging is a natural phenomenon, people try to reverse it to achieve a healthy and happy life. mume seed could be a useful ingredient in nutraceuticals and inner beauty-purpose foods. Moreover, PmRS treatment reduced c-Jun N-terminal kinase and p38 phosphorylation compared with the UVB-treated group. MMP-1 and SIRT1 treated with PmRS were decreased and increased, respectively, at the protein level. However, mRNA expressions of tissue inhibitor of metalloproteinase-1 and SIRT1 were upregulated by PmRS treatment. PmRS downregulated MMP-1 and MMP-13 compared with the UVB-irradiated group. The protective effect of PmRS treatment against UVB-mediated cell viability was observed in vitro without any cytotoxicity, and PmRS prevented UVB-induced reactive oxygen species generation in HaCaT cells. Compared with the UV-saline group, the UV-PmRS group showed increased levels of silent mating type information regulation 2 homolog 1 (SIRT1) and collagen and decreased matrix metalloproteinase- (MMP-) 1 expression. PmRS exhibited protective effects against ultraviolet- (UV-) induced skin aging in mice, confirmed by phenotypic indications, including increased collagen levels and decreased skin thickness. mume ripened seed (PmRS) was not toxic on the skin. Alternative animal tests showed that an extract of P. The Prunus mume seed is a by-product of the food industry, and we studied its potential as a food biomaterial, particularly for nutraceutical and inner beauty products.
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